Tagged: clinical research

Our Staff Discusses COVID-19 Crisis on WPTF Podcast

Posted on May 21, 2020

Aubrey Farray is the Phase I clinical manager at Wake Research in Raleigh, N.C., the headquarters of the site network ClinSearch belongs to. He recently spoke with hosts Jason Kong (WPTF) and Nicole Clagett (Transitions GuidingLights) of WPTF’s Aging Well podcast on clinical trials in the COVID-19 crisis.

In the interview, he details the process of clinical trials — explaining what participating in a clinical trial entails for those who have questions, and discusses how the elderly population can still participate in ongoing clinical trials, and do so safely during COVID-19.

Farray also tells Aging Well how Wake Research and all of its sites are keeping current clinical trials safe for all participants during the COVID-19 crisis, and emphasizes the important role clinical trials have right now in researching and testing drugs to treat COVID-19.

Listen to the full interview here:

 

Patient Testimonial: Parkinson’s Disease Clinical Research

Posted on May 7, 2020

‘The first step in finding the avenue for a cure’

In 2018, Veronica Arevalo was experiencing neurological symptoms and didn’t know what could be wrong. Her boyfriend took her to the hospital where she received a neurological exam. There, at age 48, Veronica was diagnosed with Parkinson’s disease, the disease her dad had been diagnosed with just 14 years earlier.

“I was always told it wasn’t hereditary,” Veronica said. “But when I was diagnosed in 2018, I said there had to be more to it, because there’s not a lot of information on the types that are hereditary and the types that aren’t.”

This winter, Veronica came across an ad for a Parkinson’s observational research study at Pharmacology Research Institute (PRI) in Encino, California — a research site that is a part of Wake Research, the site network ClinSearch belongs to. Upon learning that the basis of the study was giving a blood sample to look for the genetic markers associated with Parkinson’s, Veronica signed up.

“When my dad was diagnosed, I did my research, and I found that there really haven’t been that many changes or advancements from when he was diagnosed to now,” she said. “When I saw what the study was for, I said, ‘OK, this is actually something that can provide some results to where Parkinson’s is coming from and why.’”

Veronica and her boyfriend near their home in California.

Veronica and her boyfriend near their home in California.

NO KNOWN CAUSE

To date, there is no known exact cause for Parkinson’s disease. Existing research has suggested that genetic factors play a 10-15 percent role in the cause, and that those who have close relatives with Parkinson’s will have a higher chance of developing the disease in their lifetime.

Researchers have found that the genetic cause is due to specific gene mutations linked to Parkinson’s disease that are hereditary. The most frequently known genetic causes are mutations in the LRRK2 (Leucine-rich repeat kinase) gene and in the GBA (glucocerebrosidase) gene.

The study that Veronica participated in at PRI is looking for the LRRK2 genetic marker in individuals with Parkinson’s disease or whose family members have Parkinson’s disease.

“My mom didn’t believe that Parkinson’s was what I had because she believed my dad’s was caused by Agent Orange when he served in the Vietnam War,” Veronica said. “Then my dad felt responsible. So, if my results come back with this gene, I can tell him that it’s this specific marker, it’s a genetic thing, and I can put his mind at ease.”

HOPE FOR A CURE

Veronica hopes that for those who participate in this study, their results may not only give them a peace of mind, but will help contribute to finding out more about Parkinson’s disease — why it develops, a way to treat it, and possibly, finding a cure.

“Once I get my results back, then if I do have that gene, it will give me some kind of knowledge that they’re working on an advancement as to why Parkinson’s develops,” she said.

And she hopes more people affected by this disease will take the step to participate in the study and further contribute to research on Parkinson’s disease.

“People can get a little nervous sometimes about studies, but it’s very easy to do,” she said. “This is the first step in finding the avenue for a cure.”

If you or a loved one have been diagnosed with Parkinson’s Disease and you are interested in participating in our study, visit our Parkinson’s study page to find out more information and sign up.

Crohn’s Disease

Posted on February 22, 2018

Crohn’s disease causes inflammation of the digestive tract usually within the colon or the lower part of the small intestines. This inflammatory bowel disease can lead to severe diarrhea, malnutrition, weight loss, fatigue, and abdominal pain. There is no known cure for Crohn’s disease. Causes may include heredity, environment, or a faulty immune system. Other risk factors include environment, age, ethnicity, and the use of anti-inflammatory medications. Food and stress have been known to aggravate the symptoms of Crohn’s, however; it is not the cause of the disease as once thought. Crohn’s can be extremely debilitating and can lead to life threatening complications.

The symptoms of Crohn’s disease can vary from mild to severe. The more common symptoms of Crohn’s disease include:

  • Diarrhea
  • Fever
  • Fatigue
  • Abdominal pain
  • Mouth sores
  • Blood in stool
  • Loss of appetite
  • Perianal disease

In some cases inflammation of the eyes, skin, joints, liver, and bile ducts may occur. Not everyone with Crohn’s disease will experience all of these symptoms.

There is no cure for Crohn’s disease, however; there are treatment options that can help reduce symptoms and overtime can help lead to remission.

ClinSearch is currently enrolling volunteers for a clinical study testing the safety and effectiveness of an investigational medication for individuals with moderate to severe Crohn’s disease. To find out more about the study and to see if you may qualify, call our office at (423) 698-4584 or visit our website at www.clinsearch-us.com

Clinsearch is an independent clinical research center that provides ethical and safe cutting-edge medical care for our volunteers as well as high-quality research data for our sponsors with strict adherence to GCP guidelines. Headquartered in Chattanooga, Tennessee and servicing surrounding metropolitan areas, including Hamilton, Marion, Sequatchie, Catoosa, Dade and Walker Counties, and the cities of East Ridge, Soddy-Daisy, Ft. Oglethorpe, Signal Mountain, Chickamauga, Ringgold, Rossville, Cleveland, Dalton, Hixson, Harrison, Ooltewah and beyond.

 

References:

https://www.mayoclinic.org/diseases-conditions/crohns-disease/symptoms-causes/syc-20353304

Eczema (Atopic Dermatitis)

Posted on February 22, 2018

Eczema (atopic dermatitis) is a common skin condition that causes dry, red, itchy, flaky skin. These symptoms will often lead to infection causing small blisters to form that may ooze or crust over.  The severity of eczema depends upon how large an area of the skin is affected.  The more common places for eczema to appear are the face, neck, legs, arms, and scalp. Over the counter moisturizers will not relieve the most severe cases of eczema.

While there is no exact cause of eczema, people who suffer with this skin condition often have a family history of allergies such as hay fever. Eczema is thought to be a type of allergic reaction. Factors such as temperature change, food, harsh soaps, sweat, and stress can all cause eczema to flare up. There is no cure for eczema however there are treatment options available.

ClinSearch is currently enrolling volunteers for a clinical study testing the safety and effectiveness of an investigational consumer product for atopic dermatitis (eczema). To find out more about the study and to see if you may qualify, call our office at (423) 698-4584 or visit our website at www.clinsearch-us.com

Clinsearch is an independent clinical research center that provides ethical and safe cutting-edge medical care for our volunteers as well as high-quality research data for our sponsors with strict adherence to GCP guidelines. Headquartered in Chattanooga, Tennessee and servicing surrounding metropolitan areas, including Hamilton, Marion, Sequatchie, Catoosa, Dade and Walker Counties, and the cities of East Ridge, Soddy-Daisy, Ft. Oglethorpe, Signal Mountain, Chickamauga, Ringgold, Rossville, Cleveland, Dalton, Hixson, Harrison, Ooltewah and beyond.

 

References

https://www.webmd.com/skin-problems-and-treatments/eczema/eczema-basics#1

Ulcerative Colitis

Posted on February 22, 2018

Are you suffering with ulcerative colitis? This kind of inflammatory bowel disease can be quite debilitating. Ulcerative colitis, or UC, causes inflammation and ulcers to develop within the inner most lining of the large intestines (the colon and rectum). Ulcerative colitis is a disease that progresses over time and can lead to health complications if left untreated. Although there is no cure for this disease there are treatments to help relieve symptoms and even send your ulcerative colitis into remission for a long period of time. The symptoms of this inflammatory bowel disease can be so severe that it can interfere with daily activities.

Symptoms include abdominal cramping, diarrhea, blood in the stool, rectal bleeding, fever, fatigue, and weight loss. It was once believed that diet and stress level caused this disease to occur. Now health care professionals believe that there are other causes and risk factors for this disease, and that diet and stress just aggravate symptoms.  The risk factors for developing ulcerative colitis include heredity, age, family history, and even ethnicity.

Ulcerative colitis effects everyone differently; some have mild symptoms that can be easily managed, while others symptoms can be severe and interfere with daily life. Most people with ulcerative colitis will have the symptoms come and go, with months to years of remission before a flare up, while about 5-10% have the symptoms all the time.

ClinSearch is currently enrolling volunteers for a clinical study testing the safety and effectiveness of an investigational medication for individuals with ulcerative colitis. To find out more about the study and to see if you may qualify, call our office at (423) 698-4584 or visit our website at www.clinsearch-us.com

Clinsearch is an independent clinical research center that provides ethical and safe cutting-edge medical care for our volunteers as well as high-quality research data for our sponsors with strict adherence to GCP guidelines. Headquartered in Chattanooga, Tennessee and servicing surrounding metropolitan areas, including Hamilton, Marion, Sequatchie, Catoosa, Dade and Walker Counties, and the cities of East Ridge, Soddy-Daisy, Ft. Oglethorpe, Signal Mountain, Chickamauga, Ringgold, Rossville, Cleveland, Dalton, Hixson, Harrison, Ooltewah and beyond.

 

References

https://www.mayoclinic.org/diseases-conditions/ulcerative-colitis/symptoms-causes/syc-20353326

ClinSearch to Partner with the Sjögren’s Syndrome Foundation

Posted on October 16, 2017

We are excited to announce our partnership with the Sjögren’s Syndrome Foundation and to get the word out about our ongoing clinical research study of Sjögren’s Syndrome. Below is a letter the foundation has sent out on our behalf:

October 2017

Dear Sjögren’s Patient:

Each day research and clinical trials are being conducted to unveil new medications, therapies and diagnostic tools for Sjögren’s syndrome and its symptoms. Listed below is information about a Sjögren’s clinical research study being held in the greater Chattanooga area. Your participation in this study could help patients worldwide, and I hope you will consider learning more.

This new Sjögren’s clinical study is looking for men and women, age 18-75 with Sjögren’s syndrome. Qualified participants will receive study-related medication and medical exams at no cost, and compensation for travel costs.

For more information and to see if you may be eligible to participate, contact:

ClinSearch
6035 Shallowford Rd. #109
Chattanooga, TN 37421
clinsearch-us.com

Call: (423) 698-4584 or email [email protected]

If you have questions regarding the project, please contact the number listed above and not the Foundation Office.

On behalf of the millions of Sjögren’s sufferers in this country, I thank you for taking time to learn more about this study.

Sincerely,

Steven Taylor

Chief Executive Officer

To find out more about the Sjögren’s Syndrome Foundation, please visit their website at: https://www.sjogrens.org/

To learn more about our clinical research study examining the safety and effectiveness of an investigational medication for individuals with Sjögren’s syndrome, click here.

ClinSearch Awarded Coveted Research Site Award

Posted on January 24, 2017

ClinSearch is excited to announce that we have been awarded the Best Clinical Research Company – South East USA in the 2017 Biotechnology Awards. Each year, Global Health and Pharma searches for outstanding organizations working in the pharma field to highlight their work. At ClinSearch, we take pride in providing exceptional healthcare while working to expand the reaches of clinical research.

From GHP: The 2017 Biotechnology Awards are our way of spreading the word about what is a truly captivating and vital industry, whilst also acknowledging and commending the clinicians, chemists, researchers, engineers and MDs creating the way for others to follow. We are wholly dedicated to presenting this remarkable and vital industry with the admiration it so rightly deserves, whilst applying the same in-depth, thorough process and standards that establish the biotech industry itself during our rigorous judging and research process.”

The ClinSearch research team is committed to the highest standards of performance in the conduct of clinical trials completed at our facility. Our executive leadership has built a research team recruited for their analytical skills as well as their genuine compassion and ability to relate to study volunteers. Our group of professionals work together in a team environment with all members respected for their contributions to the study goals. Our staff is small enough to promote efficient communication, but large enough to build in redundancy for all critical functions within a trial.  We are honored to receive this award and excited to continue our efforts in conducting patient-serving clinical research trials.