Tagged: ClinSearch

Anal Fissures

Posted on February 22, 2018

An anal fissure is a small tear in the lower rectum which can cause pain during bowel movements. While most anal fissures heal within a couple days or weeks, some can become chronic, which may need medical treatment. Chronic anal fissure is one that hasn’t healed after 8-12 weeks.

Anal fissures are common, and affect people of all age, regardless of health. Anal fissures are caused when there is injury to the anal canal. Injury can happen due to:

  • Strain of constipation
  • Passing a large or hard stool
  • Childbirth
  • Rectal exam
  • Anal intercourse
  • Foreign object

The symptoms of an anal fissure include:

  • Pain during and/or after bowel movements (pain can be quite severe)
  • Blood on the stool or toilet paper after a bowel movement
  • Itching or irritation

The Mayo Clinic states that the best way to prevent an anal fissure is by trying to prevent constipation. This can be done by eating high-fiber foods, drinking lots of fluids, and exercising regularly.

ClinSearch is currently enrolling people with anal fissures for a clinical study testing the safety and effectiveness of an investigational injectable medication. To find out more about the study and to see if you may qualify, call our office at (423) 698-4584 or visit our website at www.clinsearch-us.com

Clinsearch is an independent clinical research center that provides ethical and safe cutting-edge medical care for our volunteers as well as high-quality research data for our sponsors with strict adherence to GCP guidelines. Headquartered in Chattanooga, Tennessee and servicing surrounding metropolitan areas, including Hamilton, Marion, Sequatchie, Catoosa, Dade and Walker Counties, and the cities of East Ridge, Soddy-Daisy, Ft. Oglethorpe, Signal Mountain, Chickamauga, Ringgold, Rossville, Cleveland, Dalton, Hixson, Harrison, Ooltewah and beyond.

 

References:

https://www.mayoclinic.org/diseases-conditions/anal-fissure/symptoms-causes/syc-20351424

https://www.webmd.com/digestive-disorders/anal-fissure-causes

 

 

Crohn’s Disease

Posted on February 22, 2018

Crohn’s disease causes inflammation of the digestive tract usually within the colon or the lower part of the small intestines. This inflammatory bowel disease can lead to severe diarrhea, malnutrition, weight loss, fatigue, and abdominal pain. There is no known cure for Crohn’s disease. Causes may include heredity, environment, or a faulty immune system. Other risk factors include environment, age, ethnicity, and the use of anti-inflammatory medications. Food and stress have been known to aggravate the symptoms of Crohn’s, however; it is not the cause of the disease as once thought. Crohn’s can be extremely debilitating and can lead to life threatening complications.

The symptoms of Crohn’s disease can vary from mild to severe. The more common symptoms of Crohn’s disease include:

  • Diarrhea
  • Fever
  • Fatigue
  • Abdominal pain
  • Mouth sores
  • Blood in stool
  • Loss of appetite
  • Perianal disease

In some cases inflammation of the eyes, skin, joints, liver, and bile ducts may occur. Not everyone with Crohn’s disease will experience all of these symptoms.

There is no cure for Crohn’s disease, however; there are treatment options that can help reduce symptoms and overtime can help lead to remission.

ClinSearch is currently enrolling volunteers for a clinical study testing the safety and effectiveness of an investigational medication for individuals with moderate to severe Crohn’s disease. To find out more about the study and to see if you may qualify, call our office at (423) 698-4584 or visit our website at www.clinsearch-us.com

Clinsearch is an independent clinical research center that provides ethical and safe cutting-edge medical care for our volunteers as well as high-quality research data for our sponsors with strict adherence to GCP guidelines. Headquartered in Chattanooga, Tennessee and servicing surrounding metropolitan areas, including Hamilton, Marion, Sequatchie, Catoosa, Dade and Walker Counties, and the cities of East Ridge, Soddy-Daisy, Ft. Oglethorpe, Signal Mountain, Chickamauga, Ringgold, Rossville, Cleveland, Dalton, Hixson, Harrison, Ooltewah and beyond.

 

References:

https://www.mayoclinic.org/diseases-conditions/crohns-disease/symptoms-causes/syc-20353304

Eczema (Atopic Dermatitis)

Posted on February 22, 2018

Eczema (atopic dermatitis) is a common skin condition that causes dry, red, itchy, flaky skin. These symptoms will often lead to infection causing small blisters to form that may ooze or crust over.  The severity of eczema depends upon how large an area of the skin is affected.  The more common places for eczema to appear are the face, neck, legs, arms, and scalp. Over the counter moisturizers will not relieve the most severe cases of eczema.

While there is no exact cause of eczema, people who suffer with this skin condition often have a family history of allergies such as hay fever. Eczema is thought to be a type of allergic reaction. Factors such as temperature change, food, harsh soaps, sweat, and stress can all cause eczema to flare up. There is no cure for eczema however there are treatment options available.

ClinSearch is currently enrolling volunteers for a clinical study testing the safety and effectiveness of an investigational consumer product for atopic dermatitis (eczema). To find out more about the study and to see if you may qualify, call our office at (423) 698-4584 or visit our website at www.clinsearch-us.com

Clinsearch is an independent clinical research center that provides ethical and safe cutting-edge medical care for our volunteers as well as high-quality research data for our sponsors with strict adherence to GCP guidelines. Headquartered in Chattanooga, Tennessee and servicing surrounding metropolitan areas, including Hamilton, Marion, Sequatchie, Catoosa, Dade and Walker Counties, and the cities of East Ridge, Soddy-Daisy, Ft. Oglethorpe, Signal Mountain, Chickamauga, Ringgold, Rossville, Cleveland, Dalton, Hixson, Harrison, Ooltewah and beyond.

 

References

https://www.webmd.com/skin-problems-and-treatments/eczema/eczema-basics#1

Ulcerative Colitis

Posted on February 22, 2018

Are you suffering with ulcerative colitis? This kind of inflammatory bowel disease can be quite debilitating. Ulcerative colitis, or UC, causes inflammation and ulcers to develop within the inner most lining of the large intestines (the colon and rectum). Ulcerative colitis is a disease that progresses over time and can lead to health complications if left untreated. Although there is no cure for this disease there are treatments to help relieve symptoms and even send your ulcerative colitis into remission for a long period of time. The symptoms of this inflammatory bowel disease can be so severe that it can interfere with daily activities.

Symptoms include abdominal cramping, diarrhea, blood in the stool, rectal bleeding, fever, fatigue, and weight loss. It was once believed that diet and stress level caused this disease to occur. Now health care professionals believe that there are other causes and risk factors for this disease, and that diet and stress just aggravate symptoms.  The risk factors for developing ulcerative colitis include heredity, age, family history, and even ethnicity.

Ulcerative colitis effects everyone differently; some have mild symptoms that can be easily managed, while others symptoms can be severe and interfere with daily life. Most people with ulcerative colitis will have the symptoms come and go, with months to years of remission before a flare up, while about 5-10% have the symptoms all the time.

ClinSearch is currently enrolling volunteers for a clinical study testing the safety and effectiveness of an investigational medication for individuals with ulcerative colitis. To find out more about the study and to see if you may qualify, call our office at (423) 698-4584 or visit our website at www.clinsearch-us.com

Clinsearch is an independent clinical research center that provides ethical and safe cutting-edge medical care for our volunteers as well as high-quality research data for our sponsors with strict adherence to GCP guidelines. Headquartered in Chattanooga, Tennessee and servicing surrounding metropolitan areas, including Hamilton, Marion, Sequatchie, Catoosa, Dade and Walker Counties, and the cities of East Ridge, Soddy-Daisy, Ft. Oglethorpe, Signal Mountain, Chickamauga, Ringgold, Rossville, Cleveland, Dalton, Hixson, Harrison, Ooltewah and beyond.

 

References

https://www.mayoclinic.org/diseases-conditions/ulcerative-colitis/symptoms-causes/syc-20353326

ClinSearch Announces Transition in Leadership Team

Posted on January 31, 2018

Welcomes Mark M. McKenzie, M.D. as Medical Director

[Chattanooga, TN] – ClinSearch, Clinical Research Specialists announces a transition in leadership at the 25-year-old clinical research site. Dr. Mark M. McKenzie is succeeding ClinSearch founder Dr. Richard A. Krause as medical director.

“I have a passion for medical care and the difference it makes in the lives of individuals”, said Mark M. McKenzie, MD. “Clinical research is essential to that effort, and as an investigator, I am committed to carrying on the mission of ClinSearch as we partner with sponsors in providing reliable data in the development of new therapies.”

Dr. McKenzie assumed leadership at ClinSearch in 2017. Dr. Krause will remain with the organization as a consultant.

About Dr. Mark M. McKenzie

Dr. McKenzie is a physician who completed medical school and residency at the Medical College of Ohio / University of Toledo.  His undergraduate degrees are from Southern Adventist University.  He practiced internal medicine in the Chattanooga area for the last 15 years and has experience as a Sub-Investigator in nearly 100 clinical research studies.

About ClinSearch

ClinSearch built a research team recruited for their analytical skills as well as their genuine compassion and ability to relate to study volunteers. This group has performed admirably in community outreach events, educating and performing health screening assessments to a diversity of community groups. The staff works an expanded day to accommodate participant schedules and will often see patients on weekends or evenings to ensure success.

ClinSearch is a wholly-owned subsidiary of Wake Research Holdings, and an integral member of its integrated network of premier investigational sites.

About Wake Research

Wake Research is an integrated network of premier investigational sites, committed to excellence, working closely with and meeting the needs of the biopharmaceutical, biotechnology, medical device and pharmaceutical industries. Wake Research‘s 13 sites are fully equipped to meet the needs of sponsors and CROs in the conduct of Phase I-IV clinical trials in a large variety of indications.

Wake Research is known for effectively combining strategic volunteer recruitment and retention with high quality clinical trial conduct, using standardized operating procedures and centralized marketing and advertising to ensure rapid subject enrollment. Wake Research has conducted over 6,000 research studies for hundreds of pharmaceutical and biotech sponsors and CROs since 1984. Wake Research’s mission is to bring novel medications, biologics and device through clinical research to as many people as possible while providing unparalleled service and exceptional value to clinical trial partners and stakeholders.

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ClinSearch to Partner with the Sjögren’s Syndrome Foundation

Posted on October 16, 2017

We are excited to announce our partnership with the Sjögren’s Syndrome Foundation and to get the word out about our ongoing clinical research study of Sjögren’s Syndrome. Below is a letter the foundation has sent out on our behalf:

October 2017

Dear Sjögren’s Patient:

Each day research and clinical trials are being conducted to unveil new medications, therapies and diagnostic tools for Sjögren’s syndrome and its symptoms. Listed below is information about a Sjögren’s clinical research study being held in the greater Chattanooga area. Your participation in this study could help patients worldwide, and I hope you will consider learning more.

This new Sjögren’s clinical study is looking for men and women, age 18-75 with Sjögren’s syndrome. Qualified participants will receive study-related medication and medical exams at no cost, and compensation for travel costs.

For more information and to see if you may be eligible to participate, contact:

ClinSearch
6035 Shallowford Rd. #109
Chattanooga, TN 37421
clinsearch-us.com

Call: (423) 698-4584 or email [email protected]

If you have questions regarding the project, please contact the number listed above and not the Foundation Office.

On behalf of the millions of Sjögren’s sufferers in this country, I thank you for taking time to learn more about this study.

Sincerely,

Steven Taylor

Chief Executive Officer

To find out more about the Sjögren’s Syndrome Foundation, please visit their website at: https://www.sjogrens.org/

To learn more about our clinical research study examining the safety and effectiveness of an investigational medication for individuals with Sjögren’s syndrome, click here.

Crohn’s Disease, Ulcerative Colitis and You

Posted on September 27, 2017

Crohn’s disease vs. ulcerative colitis

Crohn’s disease and ulcerative colitis are both chronic inflammatory diseases of the GI tract.

Ulcerative colitis involves only the colon, and Crohn’s can involve any part of the GI tract (from the mouth to anus).

Both occur most frequently in men and women between the ages of 15-35.

Symptoms vary but can include:

  • Diarrhea
  • Rectal bleeding
  • Abdominal pain
  • Weight loss
  • Liver problems
  • Kidney problems

Cause of either is unknown, but may be a combination of genetics, immune system or environment. There appears to be an over-reaction of the immune system attacking the gut.

Treatments:

There is no cure, but we can control symptoms by suppressing the immune system using:

  • Steroids
  • Anti TNF drugs
  • Vedolizumab
  • 6MP

ClinSearch has several new studies to treat Crohn’s or ulcerative colitis not responding to current treatment.

For more information on our Crohn’s study, please click here.

For more information on our ulcerative colitis study, please click here.

Contact us at (423) 698-4584 or go to our website at www.clinsearch-us.com.

 

 

Inside Insights from Spaz the Spastic Colon.

Posted on February 4, 2016

Happy Colon

 

My name is Spaz, and I’m a Spastic Colon. I am a hard worker with good intentions, but sometimes I have anger issues. This happens to be pretty common for those of us in the “business”. Did you know that nearly 15% of all the bowels in the United States have a reputation for being irritable? Unfortunately, when tummies get upset we can be a literal pain in the butt. That’s why it’s important to understand what provokes us. I have taken it upon myself to be the voice of intestines everywhere in hopes that one day we can all live in digestive peace.

Colons are sensitive beings. Second only to the brain, the digestive tract contains the largest number of nerve cells in the entire body. It’s safe to say that I have a mind of my own. (Click here to learn more about my brain, aka the Enteric Nervous System.) There are multiple interacting factors that have an effect on us, and some of us are especially hypersensitive.

Spastic Colon

Things that make me go “Grrr”

#1. Communication Issues

I’m not totally blaming the “big brain” upstairs, but I’d say that one of the underlying problems is the way she processes the sensory information I send her. We don’t always have the best communication and that can be very frustrating for both of us.

#2. Bacterial Imbalance (Dysbiosis)

Happy intestines have a healthy balance of both good and bad bacteria.  There is a constant battle going on down here between them.  In the event that a colony takes over, a chronic imbalance occurs, known as dysbiosis.  This is actually a very important insight into my psyche.  Many of the symptoms of IBS (and a host of other ailments, mental and physical) are believed to stem from intestinal dysbiosis.

#3. Leaky Gut Syndrome

Now seems like a good time to address Leaky Gut Syndrome. A leaky gut is an unhappy gut and arguably more of a symptom than a diagnosis. The small intestine is expected to simultaneously function as a sponge AND a barrier, absorbing nutrients while keeping food, bacteria and other unsavory molecules from entering the bloodstream. Leaky guts struggle with this and are often found in patients with Crohn’s, Celiac Disease and IBS. While the cause isn’t always clear the effects can lead to many problems throughout your entire body. Including but not limited to: inflammatory bowel disease; food allergies; and chronic skin problems.

There you have it folks. I hope I was able to provide some insight from the inside. Next time you think your tummy is upset, maybe you’ll have a better understanding of why. For more information on IBS, treatment options, and when to see a doctor click here.

ClinSearch has provided our community with access to clinical research trials since 1992. We serve volunteers from the greater Chattanooga area, Cleveland, Dalton, Georgia and North-Eastern Alabama with access to clinical trials like this one, currently enrolling for Crohn’s Disease. While each individual trial varies, most offer study-related investigational drug and medical exams at no cost, and compensation for your time and travel.

ClinSearch is always looking for qualified volunteers. If you have IBS, Crohn’s, Celiac Disease, or any other inflammatory bowel disorder and want to know more about new treatment options, give us a call at (423) 698-4584 or request more information here.

Fibromyalgia is a woman.

Posted on November 18, 2015

FibroHi, my name is Fibromyalgia. Maybe you’ve heard of me, but like most women I am poorly understood. While I pride myself on being so mysterious, I think I need to set the record straight on a few things. First of all, I am real. If you don’t believe me, ask one of the 5 million people in the United States that live with me every day. I mean, how much pain and debilitation does a gal have to cause before someone starts taking her seriously!? Sorry, I tend to get emotional. I just think it’s time I get the respect I deserve. If you want to know more about me, keep reading. I’ll open up about causes, symptoms, and who’s at risk of becoming my new best friend.

Where did I come from? Oh wouldn’t you like to know. I’m not ready to reveal all just yet. However, I’ll hint that it may be due to problems in the brain, spinal cord and nerves.

I prefer to keep company with other women, but not exclusively. The important qualities I look for are as follows:

  • Physical/Emotional Trauma
  • Family history of me
  • Certain infections
  • Autoimmune diseases

I do love my job, and I am proficient in initiating discomfort in the following areas:

  • Deep muscle pain
  • Painful tender points
  • Morning stiffness
  • Anxiety/Depression
  • Fatigue
  • Headaches
  • Irritable Bowel
  • Sleep Problems (Oh did I wake you?)
  • Numbness/Tingling
  • Urinary problems

One of my biggest pet peeves is when people get me confused with, Arthur. I’m sure you know him as Arthritis. Yes, Arthur is a pain but he only causes pain in the joints. I know I risk sounding braggadocios here, but I can cause pain throughout your entire body! And here’s the real kicker. I’m hard to diagnose. There is no specific blood test or X-ray to prove my existence! However, with the right evaluation of tender points, a diagnosis is not impossible. I told you I was mysterious.

Okay, let’s talk about treatment. Science is finally starting to take me seriously. You may find relief using some of the following options:

  • Pain Medication
  • Antidepressants such as Cymbalta
  • Lyrica (Calms excited nerves)
  • Savella
  • Physical Therapy
  • Medical Marijuana
  • Acupuncture
  • Meditation

Also, I am honored to announce, ClinSearch is currently evaluating a new medication to treat ‘yours truly’. Please contact them at (423) 698-4584 or go to the website for more information.

Migraine. My Brain. My Headache

Posted on September 29, 2015

Migraine

Got migraines on your mind?  If you’re one of the 30-47 million Americans that suffer from these monster headaches, it’s safe to assume that you do. And whether your migraines rage on for hours—or days—their presence can certainly be debilitating.

Pain in the Brain: Understanding Migraines

To know how to treat migraines, it helps to understand where they come from. A migraine is more than a headache. It’s a complex condition precipitated by both genetic and environmental factors (I’ll touch more on potential triggers in a bit). There is still so much unknown about migraines, but we do know that when they “attack” a chemical imbalance is underway in the brain. Serotonin, one of the good chemicals, helps to regulate pain in the nervous system. During an attack, these levels drop, causing a release of another substance called neuropeptides. The neuropeptide, a Calcitonin Gene-Related Peptide (CGRP), causes vasodilation of the blood vessels. Studies show that CGRP levels increase during a migraine and this may be a major cause behind the headache.

Are you at risk?

Risk factors vary from person to person, however if migraines run in your family you are more likely to be plagued with them as well. Other factors include:

  • Age—Migraines usually strike before the age of 40
  • Gender—Women are three times more likely to get migraines than men
  • Pregnancy

Symptoms

Some individuals will experience an aura that develops right before an episode. Attacks can last anywhere from 4 to 72 hours. Usually migraines will cause sharp or pulsating pain on one side of the head. This pain is exacerbated by light and sound, and is often accompanied by nausea and vomiting. Many variables are known to trigger migraines, and these also vary per person.

Some triggers include:

  • Sensory stimulation
    • Bright lights
    • Loud sounds
    • Unusual smells
  • Foods
    • Cheese
    • Salt
    • Processed foods
    • Artificial sweeteners (such as aspartame and monosodium glutamate)
    • Highly caffeinated drinks
    • Alcoholic beverages (especially wine)
  • Hormones (migraines may precede menstrual cycle)
  • Pregnancy
  • Birth control pills
  • Nitroglycerin
  • Change in weather
  • Intense physical activity (including sex)
  • Stress
  • Too much or too little sleep

When to see a doctor. You should make an appointment with your doctor if you experience any of the following symptoms.

  • Fever
  • Stiff neck
  • Confusion
  • Seizure
  • Double vision
  • Weakness
  • Trouble speaking
  • New (unusually intense) headache after 50 years of age
  • If symptoms worsen with cough, exertion, or straining

In short, if you find yourself experiencing “the worst headache ever” you may want to see your doctor.

Acute treatment options include:

Chronic prevention options include:

Additional options with less evidence of efficacy include:

Latest prevention concept:

ClinSearch is  currently conducting a study to evaluate the efficacy of a treatment that will block CGRP, the chemical in the brain that causes blood vessels to dilate.  If you are interested in learning more about this trial, please call (423) 698-4584 or visit us at ClinSearch.com