Tagged: Crohn’s Disease

October 2018 Newsletter

Posted on October 16, 2018

October 2018 Newsletter

ClinSearch would like to keep you up to date.

Our monthly newsletter details new studies and events happening at our site. Our website has several resources to learn more about the clinical trials process. We encourage you to read and share these links with friends and family who may be interested.

Volunteer Referral Program

Suggest a friend and receive a $50 referral bonus.
Learn more here

 Featured Studies

Rosacea clinical trial
Uterine Fibroids

Planning your life around heavy periods shouldn’t be the norm. Consider a research study for uterine fibroids.

Learn more here:
Uterine Fibroids Study

Overactive Bladder clinical trial
Overactive Bladder (OAB)

If you are a women who experiences the symptoms of OAB, consider joining our clinical research study.

Learn more here:
OAB Study

Crohn’s Disease

If you have moderate to severely active Crohn’s Disease and are between 18 to 75 years of age, you may qualify for our current study.

Learn more here:
Crohn’s Disease Study

Other Studies

Check out our complete list of enrolling volunteer studies here…

Active clinical trial studies

Want to be notified whenever a new volunteer study matches your interests?

Complete a volunteer sign-up form

Crohn’s Disease

Posted on February 22, 2018

Crohn’s disease causes inflammation of the digestive tract usually within the colon or the lower part of the small intestines. This inflammatory bowel disease can lead to severe diarrhea, malnutrition, weight loss, fatigue, and abdominal pain. There is no known cure for Crohn’s disease. Causes may include heredity, environment, or a faulty immune system. Other risk factors include environment, age, ethnicity, and the use of anti-inflammatory medications. Food and stress have been known to aggravate the symptoms of Crohn’s, however; it is not the cause of the disease as once thought. Crohn’s can be extremely debilitating and can lead to life threatening complications.

The symptoms of Crohn’s disease can vary from mild to severe. The more common symptoms of Crohn’s disease include:

  • Diarrhea
  • Fever
  • Fatigue
  • Abdominal pain
  • Mouth sores
  • Blood in stool
  • Loss of appetite
  • Perianal disease

In some cases inflammation of the eyes, skin, joints, liver, and bile ducts may occur. Not everyone with Crohn’s disease will experience all of these symptoms.

There is no cure for Crohn’s disease, however; there are treatment options that can help reduce symptoms and overtime can help lead to remission.

ClinSearch is currently enrolling volunteers for a clinical study testing the safety and effectiveness of an investigational medication for individuals with moderate to severe Crohn’s disease. To find out more about the study and to see if you may qualify, call our office at (423) 698-4584 or visit our website at www.clinsearch-us.com

Clinsearch is an independent clinical research center that provides ethical and safe cutting-edge medical care for our volunteers as well as high-quality research data for our sponsors with strict adherence to GCP guidelines. Headquartered in Chattanooga, Tennessee and servicing surrounding metropolitan areas, including Hamilton, Marion, Sequatchie, Catoosa, Dade and Walker Counties, and the cities of East Ridge, Soddy-Daisy, Ft. Oglethorpe, Signal Mountain, Chickamauga, Ringgold, Rossville, Cleveland, Dalton, Hixson, Harrison, Ooltewah and beyond.




Crohn’s Disease, Ulcerative Colitis and You

Posted on September 27, 2017

Crohn’s disease vs. ulcerative colitis

Crohn’s disease and ulcerative colitis are both chronic inflammatory diseases of the GI tract.

Ulcerative colitis involves only the colon, and Crohn’s can involve any part of the GI tract (from the mouth to anus).

Both occur most frequently in men and women between the ages of 15-35.

Symptoms vary but can include:

  • Diarrhea
  • Rectal bleeding
  • Abdominal pain
  • Weight loss
  • Liver problems
  • Kidney problems

Cause of either is unknown, but may be a combination of genetics, immune system or environment. There appears to be an over-reaction of the immune system attacking the gut.


There is no cure, but we can control symptoms by suppressing the immune system using:

  • Steroids
  • Anti TNF drugs
  • Vedolizumab
  • 6MP

ClinSearch has several new studies to treat Crohn’s or ulcerative colitis not responding to current treatment.

For more information on our Crohn’s study, please click here.

For more information on our ulcerative colitis study, please click here.

Contact us at (423) 698-4584 or go to our website at www.clinsearch-us.com.

Crohn’s Disease

Posted on June 6, 2017

1.4 million Americans live with Crohn’s disease.

Crohn’s disease is usually diagnosed between the age 15-30. Additionally, 5-20% of individuals with Crohn’s have a family history of the disease.

Though the cause is unknown, we know the symptoms are caused by a hyperactive immune system attacking the gut. Crohn’s may involve any part of the GI tract, but usually the distal small bowel (ileum) and the colon.

Symptoms vary depending on the section of the gut involved, but usually include:

  • Diarrhea (with possible constipation)
  • Rectal bleeding if colon is involved
  • Weight loss
  • Fever
  • Abdominal pain
  • Fatigue
  • Loss of appetite

Complications include obstructions, fissures in the rectum, fistulas, cancer and perforation. Crohn’s may also involve areas outside the GI tract such as eyes, skin, kidney stones and joints. There is no current cure, but patients may go into remission with medication.

There are several different treatments including:

  • 5 ASA (special aspirin)
  • Steroids
  • Immune modifiers (imuran, 6MP)
  • Biologics (Remicaid, Humira)

Surgery is a last resort since many patients have recurrent disease despite surgery. Most drugs suppress the immune system with increased risk of infection and cancer.

We are studying 2 new types of treatment:

  1. Triple antibiotics designed to kill MAP bacteria that may be the cause of Crohn’s in some patients.
  2. New type of oral treatments that will normalize the immune system rather than suppress it.

To see if you qualify for one of our enrolling studies, visit our website here, contact us at 423-698-4584.

Crohn’s Disease Research at ClinSearch

Posted on February 7, 2017

Fighting Crohn’s Disease

Several treatments exist including non-drug treatments, and new research is under way

Do you have or know someone with Crohn’s disease? We would like to show you why we need research to discover better treatments.

About Crohn’s disease

Crohn’s is a chronic inflammatory bowel disease (IBD) that can involve any part of the GI tract, but is most common in the distal small bowel (ileum). It can also affect eyes, skin, liver and joints (it is a system disease). There are 700,000 people with Crohn’s in the USA. Most Crohn’s cases often start between ages 15-35.

The exact cause of Crohn’s is unknown, but may be a combination of factors (genetics, environment and an overactive immune system).  The immune system is your body’s way of fighting infection. In Crohn’s, something triggers the immune system to overreact and release chemicals that promote inflammation. Risk factors include smoking or living in an industrialized nation. Being white and having a Jewish heritage.

Symptoms may vary dependent on its location, but it usually causes abdominal pain, fever, weight loss, loss of appetite and loss of energy. If the colon is involved, there is diarrhea with blood and pain. If the small bowel is involved, there is weight loss, possible obstruction and abdominal pain. 70% of patients eventually need surgery.  Complications include perforation of the bowel, small bowel obstruction, fistulas connecting bowel to bladder, vagina, skin and adjacent bowel, and increased risk of colon cancer.

Crohn’s disease can be diagnosed by colonoscopy, CAT Scan, MRI, capsule endoscopy (swallow a small capsule that transmits pictures of the small bowel). There are also blood tests and stool studies. There are many different ways to treat Crohn’s, but they usually suppress the immune system resulting in possible infection and higher risk of cancer. Non drug treatment could include avoiding NSAIDS (Motrin, etc.) and avoiding high fiber if small bowel is involved. Some patients do better avoiding dairy products, gluten and limiting alcohol and caffeine.

Current treatments include:

  1. Oral 5 amino salicylates (Azulfidine, Asacol, Pentasa, Lialda, etc.)
  2. Steroids
  3. Immuno-suppressants (imuran and 6MP)
  4. TNF inhibitor (biologics) such as remade, Humira and Cimzia
  5. Methotrexate
  6. Entyvio (work on cells lining the gut to reduce lymphocyte migration and thus reduce inflammation)
  7. Stellar (inhibits IL12 and IL23 blocking inflammation cascade)
  8. Antibiotics (Flagyl, Cipro)
  9. Non prescription antidiarrheal, vitamins, supplements and probiotics

Our new treatment includes:

  1. Triple antibiotic to treat MAP (a bacteria similar to TB) that could be the trigger in some people causing Crohn’s
  2. Antisense drug to normalize rather than suppress the immune system

To check for new and existing clinical trials, check our enrolling studies page.

There is no cure, but—with treatment—Crohn’s can go into remission.

Inside Insights from Spaz the Spastic Colon.

Posted on February 4, 2016

Happy Colon


My name is Spaz, and I’m a Spastic Colon. I am a hard worker with good intentions, but sometimes I have anger issues. This happens to be pretty common for those of us in the “business”. Did you know that nearly 15% of all the bowels in the United States have a reputation for being irritable? Unfortunately, when tummies get upset we can be a literal pain in the butt. That’s why it’s important to understand what provokes us. I have taken it upon myself to be the voice of intestines everywhere in hopes that one day we can all live in digestive peace.

Colons are sensitive beings. Second only to the brain, the digestive tract contains the largest number of nerve cells in the entire body. It’s safe to say that I have a mind of my own. (Click here to learn more about my brain, aka the Enteric Nervous System.) There are multiple interacting factors that have an effect on us, and some of us are especially hypersensitive.

Spastic Colon

Things that make me go “Grrr”

#1. Communication Issues

I’m not totally blaming the “big brain” upstairs, but I’d say that one of the underlying problems is the way she processes the sensory information I send her. We don’t always have the best communication and that can be very frustrating for both of us.

#2. Bacterial Imbalance (Dysbiosis)

Happy intestines have a healthy balance of both good and bad bacteria.  There is a constant battle going on down here between them.  In the event that a colony takes over, a chronic imbalance occurs, known as dysbiosis.  This is actually a very important insight into my psyche.  Many of the symptoms of IBS (and a host of other ailments, mental and physical) are believed to stem from intestinal dysbiosis.

#3. Leaky Gut Syndrome

Now seems like a good time to address Leaky Gut Syndrome. A leaky gut is an unhappy gut and arguably more of a symptom than a diagnosis. The small intestine is expected to simultaneously function as a sponge AND a barrier, absorbing nutrients while keeping food, bacteria and other unsavory molecules from entering the bloodstream. Leaky guts struggle with this and are often found in patients with Crohn’s, Celiac Disease and IBS. While the cause isn’t always clear the effects can lead to many problems throughout your entire body. Including but not limited to: inflammatory bowel disease; food allergies; and chronic skin problems.

There you have it folks. I hope I was able to provide some insight from the inside. Next time you think your tummy is upset, maybe you’ll have a better understanding of why. For more information on IBS, treatment options, and when to see a doctor click here.

ClinSearch has provided our community with access to clinical research trials since 1992. We serve volunteers from the greater Chattanooga area, Cleveland, Dalton, Georgia and North-Eastern Alabama with access to clinical trials like this one, currently enrolling for Crohn’s Disease. While each individual trial varies, most offer study-related investigational drug and medical exams at no cost, and compensation for your time and travel.

ClinSearch is always looking for qualified volunteers. If you have IBS, Crohn’s, Celiac Disease, or any other inflammatory bowel disorder and want to know more about new treatment options, give us a call at (423) 698-4584 or request more information here.